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cUMP hydrolysis by PDE3A

As previously reported, the cardiac phosphodiesterase PDE3A hydrolyzes cUMP. Moreover, cUMP-degrading activity was detected in cow and dog hearts several decades ago. Our aim was to characterize the enzyme kinetic parameters of PDE3A-mediated cUMP hydrolysis and to investigate whether cUMP and... Full description

1st Person: Berrisch, Stefan
Additional Persons: Ostermeyer, Jessica; Kaever, Volkhard; Kälble, Solveig; Hilfiker-Kleiner, Denise; Seifert, Roland; Schneider, Erich H
Source: in Naunyn-Schmiedeberg's archives of pharmacology (Berlin : Springer), Vol. 390, No. 3 (2017), p. 269-280
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Type of Publication: Article
Language: English
Published: 2017
Online Access: full-text
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