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Human profilin 1 is a negative regulator of CTL mediated cell‐killing and migration

The actin‐binding protein profilin1 (PFN1) plays a central role in actin dynamics, which is essential for cytotoxic T lymphocyte (CTL) functions. The functional role of PFN1 in CTLs, however still remains elusive. Here, we identify PFN1 as the only member of the profilin family expressed in... Full description

1st Person: Schoppmeyer, Rouven
Additional Persons: Zhao, Renping; Cheng, He; Hamed, Mohamed; Liu, Chen; Zhou, Xiao; Schwarz, Eva C; Zhou, Yan; Knörck, Arne; Schwär, Gertrud; Ji, Shunrong; Liu, Liang; Long, Jiang; Helms, Volkhard; Hoth, Markus; Yu, Xianjun; Qu, Bin
Source: in European journal of immunology (Weinheim : Wiley VCH), Vol. 47, No. 9 (2017), p. 1562-1572
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Type of Publication: Article
Language: English
Published: 2017
Online Access: full-text
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